Scientists have uncovered a completely new structure inside mammalian cells, dubbed the hemifusome. These tiny bubble-like organelles — even smaller than mitochondria — went unnoticed until now because they blended into background “noise.”
Using advanced cryo-electron tomography, researchers spotted strange double-vesicle shapes: a small sac half-fused onto a larger one. They believe hemifusomes act as cellular cleaners, collecting and recycling unwanted proteins — a role that could be vital in preventing diseases like Alzheimer’s.
The team also found hemifusomes across many cell types and species, suggesting they’re a fundamental part of life. Understanding how they form and work could open the door to treatments for genetic and neurodegenerative disorders.
RESEARCH PAPER 📄
DOI: 10.1038/s41467-025-59887-9
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