Scientists find a way to turn Triple-negative breast cancer cells back into normal ones.
Scientists have discovered a way to tackle one of the deadliest forms of breast cancer—triple-negative breast cancer (TNBC)—by using the cancer cells’ natural ability to change and nudging them to behave more like healthy breast tissue. By blocking a protein called PLK1, researchers were able to increase estrogen receptor alpha (ERα) in these cells, causing them to stop dividing, start dying, and lose their tumor-forming abilities, effectively reversing their aggressive behavior.
This approach, known as differentiation therapy, which has worked for some blood cancers, now shows promise for treating solid tumors like breast cancer, with the drugs involved already in clinical trials and ongoing research exploring combining this therapy with immunotherapy to boost effectiveness.
RESEARCH PAPER 📄
PMID: 36008466
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